Keeping on schedule Reshaping assays Evaluating hits

The contributions from Biacore technology continue to have a widening impact on all aspects of the drug discovery process in today’s pharmaceutical industry. As biosensor technology became a practical reality in the laboratory during the early 1990s, it was readily accepted by the scientific community as a powerful analytical technique for evaluating the kinetic parameters of molecular interactions, such as protein-protein and protein-nucleic acid. Where historically such measurements were made indirectly or by chemically modifying one or all of the interactants, thus introducing the potential for altering the natural kinetic characteristics of the interactants, a technique is now available that can measure these parameters less intrusively. And, where drug design/discovery relies on understanding structure-function relationships between biomolecules, results from Biacore systems complement structural studies with detailed kinetic data utilizing relatively fast methodologies and consuming small amounts of precious reagents. Stay on track in drug discovery Growing impact of Biacore on drug discovery